Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK124883-07
Inflammatory Stress Promotes Clonal Expansion of DNMT3A-mutant HSCs
Recipient
Washington University
Award Amount
$440,303.00
Ceiling
$440,303.00
Awarded
March 09, 2026
Identifier
5R01DK124883-07
NIH NIDDK awarded $440,303 for research on inflammatory stress promoting clonal expansion of DNMT3A-mutant hematopoietic stem cells, relevant to blood disease prevention.
Description
This project aims to investigate the role of inflammatory signals in promoting clonal expansion of DNMT3A-mutant hematopoietic stem cells, with potential implications for preventing blood diseases such as myelodysplastic syndromes. The award is funded by the NIH's NIDDK, with a total budget of $440,303 for fiscal year 2026. The project is associated with the study section 'Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]'.