Award
National Institute of Allergy and Infectious Diseases 5R01AI104878-08
Watching conformational rearrangements in picornavirus replication proteins
Recipient
Pennsylvania State University, The, University Park, PA, United States
Award Amount
$387,285.00
Ceiling
$387,285.00
Awarded
July 17, 2024
Identifier
5R01AI104878-08
This NIH-funded project studies the structural dynamics of the picornavirus 3CD protein to understand its multifunctional roles in virus replication, aiming to identify antiviral targets against emerging RNA viruses.
Description
The project aims to elucidate structural states sampled by the picornavirus 3CD protein responsible for its functions and differentiate it from related 3C and 3D proteins. Characterization of these states will aid in developing antiviral strategies against pathogens like rhinovirus, enterovirus, coronavirus, and poliovirus.