Award
NIH Reporter #11326724
Developmental pyrethroid exposure in the prairie vole as a model of environmental risk for autism
Recipient
University of Toledo Health Science Campus, Toledo, OH
Award Amount
$592,124.00
Ceiling
$592,124.00
Awarded
February 05, 2026
Identifier
11326724
This NIH-funded project studies the effects of developmental exposure to pyrethroid pesticides on autism-related neurodevelopmental outcomes using prairie voles as a model, focusing on behavioral and molecular impacts.
Description
The project investigates the impact of developmental exposure to pyrethroid pesticides, specifically deltamethrin, on neurodevelopmental disorders such as autism. Using prairie voles as a model, the study aims to assess dose-dependent behavioral and molecular effects, including disruptions in circadian rhythms, hyperactivity, repetitive behaviors, and social interactions. The research involves exposing pregnant prairie vole females to varying doses of deltamethrin and evaluating offspring through laboratory assays, natural outdoor enclosures, and multiomics molecular analyses.