Award
National Heart, Lung, and Blood Institute 1K08HL181477-01A1
Colon cancer mediates arterial remodeling through smooth muscle cell phenotypic changes via PDGFR-B signaling
Recipient
University of Colorado Denver
Award Amount
$163,285.00
Ceiling
$163,285.00
Awarded
June 25, 2026
Identifier
1K08HL181477-01A1
A research project funded by the National Heart Lung and Blood Institute to study the mechanisms by which colon cancer affects arterial remodeling through PDGFR-B signaling, aiming to identify genetic risk factors and translate findings into treatments.
Description
This project aims to elucidate mechanisms of vascular remodeling in colon cancer patients, focusing on PDGF-B signaling and genetic risk factors, with the goal of translating findings into clinical interventions. It leverages innovative cell and animal modeling, single cell transcriptomics and epigenetics, and large-scale human genetic data to understand how colon cancer interacts with the vascular system and shared inherited modulators of risk for both diseases.