Award
National Cancer Institute 5R21CA287351-02
Characterize the metabolic landscape of ARID1A-mutated ovarian cancer
Recipient
University of Minnesota
Award Amount
$176,280.00
Ceiling
$176,280.00
Awarded
December 08, 2025
Identifier
5R21CA287351-02
Research project funded by the National Cancer Institute to study mitochondrial signatures and vulnerabilities in ARID1A-mutated ovarian clear cell carcinoma, aiming to develop targeted therapies.
Description
This project aims to identify specific proteomic and functional mitochondrial signatures associated with ARID1A deficiency in ovarian clear cell carcinoma (OCCC) tumors. It will perform a genetic screen of mitochondrial electron transport chain components in ARID1A-proficient and deficient cells to uncover therapeutic vulnerabilities for ARID1A-deficient tumors, potentially leading to targeted therapies.