Award
National Heart, Lung, and Blood Institute 1K08HL178490-01
The dynamic role of the alveolar macrophage during pulmonary bacterial infection
Recipient
University of Washington, Seattle, WA, United States
Award Amount
$161,890.00
Ceiling
$161,890.00
Awarded
August 20, 2025
Identifier
1K08HL178490-01
Dr. Sarah Baker's research investigates the role of alveolar macrophages in the immune response to Gram-negative bacterial pulmonary infections, particularly melioidosis caused by Burkholderia pseudomallei. The study uses murine models and innovative methods to understand host-pathogen interactions and aims to develop host-directed therapeutics.
Description
This project aims to elucidate the role of alveolar macrophages in bacterial pneumonia, focusing on their immune functions, interaction with Burkholderia spp., and their role during recovery from infection. The research involves in vitro and in vivo studies, immunomodulatory polymers, and chimeric mouse models to understand host-pathogen interactions and develop potential therapeutics.