Award
NIH Reporter #5R01NS140365-02
Role of NFKBIA Deficiency in Subverting Neural Progenitor Commitment Toward Gliomagenesis
Recipient
University of Miami School of Medicine, Coral Gables, FL, United States
Award Amount
$599,268.00
Ceiling
$599,268.00
Awarded
July 22, 2026
Identifier
5R01NS140365-02
NIH awarded a grant to study how NFKBIA deficiency affects neural progenitor cells leading to glioblastoma, focusing on chromatin regulation mechanisms.
Description
This research aims to demonstrate that abnormalities in dynamic chromatin regulation during brain lineage specification promote gliomagenesis. The study will define processes and identify molecules involved in chromatin-regulated cell fate-switches that drive the trajectory from neural progenitor cells to glioblastoma. The research is relevant to NIH’s mission of generating fundamental knowledge to reduce the burden of gliomas.