Award
NIH Reporter #1R35GM165605-01
Saturable Adsorption as a Central Determinant of Drug Penetration in Complex Biological Tissues
Recipient
University of Michigan at Ann Arbor
Award Amount
$419,823.00
Ceiling
$419,823.00
Awarded
August 03, 2026
Identifier
1R35GM165605-01
Research grant awarded to University of Michigan at Ann Arbor by National Institute of General Medical Sciences to develop predictive models and interventions for drug delivery in complex biological tissues, focusing on adsorption-limited transport.
Description
This project aims to establish a predictive science of adsorption-limited transport to improve drug delivery in complex biological tissues. It involves mapping drug chemistry interactions, developing predictive models, and designing interventions to optimize drug penetration, especially for antibiotics in airway mucus and biofilms. The work will generalize to biologics, nanoparticles, and oncology applications.