Award
NIH Reporter #11384264
The Role of PICALM in Regulating Neurogenesis in Alzheimer's Disease
Recipient
University of Illinois at Chicago
Award Amount
$55,114.00
Ceiling
$55,114.00
Awarded
September 02, 2026
Identifier
11384264
Research project funded by the National Institute on Aging to study the role of the PICALM gene in adult hippocampal neurogenesis and its impact on memory impairment in Alzheimer's disease.
Description
This project aims to investigate the role of PICALM, a gene linked to late-onset Alzheimer's disease (LOAD), in hippocampal neurogenesis and memory impairment. It focuses on understanding how PICALM influences neuronal maturation, b-APP metabolism, and contributes to pathology and cognitive deficits in Alzheimer's disease.