Award
University of Maryland, Baltimore 5U01DC013817-10
Cell Type Specific Transcriptional Cascades in Inner Ear Development
Recipient
University of Maryland Baltimore
Award Amount
$490,911.00
Ceiling
$490,911.00
Awarded
November 26, 2024
Identifier
5U01DC013817-10
Award for research on transcriptional cascades in inner ear development, focusing on transcription factors RFX and IKZF2 in outer hair cell differentiation and survival, including transcriptomic and epigenetic mapping and mouse model development.
Description
This project focuses on the molecular mechanisms underlying inner ear sensory cell development, specifically the role of transcription factors RFX and IKZF2 in outer hair cell differentiation and survival. The research aims to generate transcriptomic and epigenetic maps, validate candidate genes, and develop mouse models for further study.