Award
University of California, San Francisco 11284081
Elucidating the Role of AIRE and Tumor Associated Aire-expressing Cells in Tumor Growth and Immune Evasion
Recipient
University of California, San Francisco
Award Amount
$42,633.00
Ceiling
$42,633.00
Awarded
March 04, 2026
Identifier
11284081
Research project awarded to University of California, San Francisco to study the role of AIRE and Aire-expressing cells in tumor growth and immune evasion using advanced cellular and genetic techniques.
Description
The project focuses on investigating the role of peripheral AIRE expression and tumor-associated Aire-expressing cells in tumor progression and immunity. The research involves single cell analysis, CyTOF, flow cytometry, and in vivo assays using genetic mouse models. The work aims to characterize AIRE expression in tumor-resident immune cells and identify novel pathways relevant to therapeutic resistance. Conducted at UCSF with mentorship from experts in immunology and computational analysis.