Award
NIH Reporter #1R21AG092247-01A1
Role of APP-related circRNAs induced by HIV-1 infection in beta-amyloid formation
Recipient
Temple University of the Commonwealth, Philadelphia, PA, USA
Award Amount
$435,875.00
Ceiling
$435,875.00
Awarded
August 06, 2025
Identifier
1R21AG092247-01A1
Research project funded by NIH to study the role of APP-related circular RNAs in beta-amyloid formation linked to HIV-1 infection and neurocognitive disorders.
Description
This project investigates the role of circular RNAs (circRNAs) derived from the APP gene, specifically hsa_circ_0007556 and circ_0004381, in the formation of beta-amyloid (A) in the context of HIV-1 infection. The study aims to understand how HIV-1 dysregulates these circRNAs and their involvement in A accumulation, which is associated with neurocognitive disorders similar to Alzheimer's disease. The research utilizes 2D and 3D culture models, including HIV-infected human cerebral organoids, to explore the mechanisms and potential therapeutic targets.