Award
National Institute on Drug Abuse 5DP1DA053719-05
MR-guided focused ultrasound to eradicate CNS viral reservoirs and promote neurogenesis in the HIV-infected brain
Recipient
University of Maryland Baltimore
Award Amount
$1,081,500.00
Ceiling
$1,081,500.00
Awarded
April 28, 2026
Identifier
5DP1DA053719-05
The award supports research using MR-guided focused ultrasound to enhance delivery of antiretroviral drugs to the brain to eradicate HIV reservoirs and promote neurogenesis, with potential clinical translation.
Description
This project aims to use MR-guided focused ultrasound (MRgFUS) to safely and transiently open the blood-brain barrier (BBB) to maximize the delivery of long-acting slow-release antiretroviral drugs (ARVs) and eliminate HIV reservoirs in the brain. The approach involves optimizing delivery in rodent models and translating findings to human studies, with potential for clinical application.