National Institute of Neurological Disorders and Stroke 1R01NS144584-01A1

Metabolic basis for oligo-vascular interactions in white matter development and injury

This NIH-funded project investigates the metabolic interactions between oligodendroglia and vasculature in neonatal brain development and injury, aiming to uncover mechanisms that could lead to therapeutics for neonatal hypoxic-ischemic brain injury.

Description

The project aims to understand how oligodendroglia obtain metabolic support from the white matter vasculature in normal development and how this process is affected in neonatal hypoxic-ischemic brain injury. It focuses on endothelial-apelin signaling and its role in white matter vascularization and myelination, investigating the regulation by OPCs, effects on cerebrovascular tone, glucose uptake, and vascularization, and the impact of hypoglycemia on myelination and oligodendrocyte metabolism.

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