Award
National Cancer Institute 2R42CA285005-03
Development of synthetic heparin to protect liver graft from ischemia reperfusion injury during transplantation
Recipient
Not specified
Award Amount
$775,669.00
Ceiling
$775,669.00
Awarded
September 08, 2025
Identifier
2R42CA285005-03
Award for developing synthetic heparin to protect liver grafts from ischemia reperfusion injury during transplantation, involving preclinical studies and aiming to improve liver transplant outcomes.
Description
Developing a carbohydrate-based reagent, dekaparin, to reduce ischemia-reperfusion injury in liver transplantation. The project involves preclinical studies, including models in pigs and rats, and ex vivo human liver models. The goal is to increase the utilization of extended criteria donor (ECD) livers.