Award
National Institute of General Medical Sciences 5R35GM158408-02
Molecular mechanisms of alkane hydroxylase (AlkB) reactivity and selectivity
Recipient
Barnard College
Award Amount
$346,634.00
Ceiling
$346,634.00
Awarded
June 23, 2026
Identifier
5R35GM158408-02
Research project funded by NIGMS to study the molecular mechanisms and reactivity of AlkB enzymes, focusing on their structure, function, and environmental and health implications.
Description
This project targets structure/function relationships in alkane monooxygenases (AlkB), a member of the class-III diiron protein family, to understand reaction mechanisms and factors controlling reaction scope. It involves mechanistic work on AlkB variants, spectroscopic characterization, mining a large library of AlkB enzymes, and exploring new AlkB families and their reactivity, with implications for human and environmental health.