Award
National Institute of General Medical Sciences 5R35GM126956-08
Discovery and mechanisms of biosynthetic enzymes
Recipient
Utah State Higher Education System--University of Utah
Award Amount
$539,000.00
Ceiling
$539,000.00
Awarded
August 11, 2025
Identifier
5R35GM126956-08
This NIH-funded project aims to discover and understand the mechanisms of biosynthetic enzymes involved in producing diverse natural products. It employs biochemical, structural, and spectroscopic methods to study enzyme function and discover new enzymes, contributing to therapeutic development.
Description
The project focuses on elucidating the mechanisms of enzymes that employ radical transformations in the biosynthesis of ribosomally produced and posttranslationally modified peptides. It uses biochemical, structural, and spectroscopic techniques to probe enzyme mechanisms, establish structure-function relationships, and discover novel biosynthetic enzymes. The research aims to understand enzyme mechanisms in natural product biosynthesis, which has implications for disease processes and therapeutic development.