Award
National Cancer Institute 5R01CA207513-10
Role of KLHL6 inactivation in mature B-cell malignancies
Recipient
University of Pennsylvania
Award Amount
$406,250.00
Ceiling
$406,250.00
Awarded
January 19, 2026
Identifier
5R01CA207513-10
NIH grant awarded to University of Pennsylvania to study the role of KLHL6 inactivation in mature B-cell malignancies, focusing on its impact on lymphoma progression and therapy resistance.
Description
The project aims to understand the ubiquitin-based regulation of B-cell lymphoma onset and progression, focusing on the role of KLHL6 as a master regulator and tumor suppressor of NOTCH signaling. The research involves modeling loss of KLHL6 in a mouse model of DLBCL and studying how impairment of the NOTCH pathway affects therapy efficacy.