Award
National Institute of Allergy and Infectious Diseases 1R01AI188782-01A1
pH-Dependent Switching of ESX-1 Substrates in Mycobacterial Pathogenesis
Recipient
University of Notre Dame, IN, United States
Award Amount
$659,122.00
Ceiling
$659,122.00
Awarded
August 11, 2025
Identifier
1R01AI188782-01A1
This NIH-funded project investigates the mechanisms by which pathogenic mycobacteria use the ESX-1 secretion system to lyse phagosomes under different pH conditions, aiming to understand substrate switching and its role in infection.
Description
Research project to determine how ESX-1 secretion promotes lysis in response to varying pH in vitro and during infection, focusing on mycobacterial pathogenesis and substrate switching in response to acidic pH.