Award
NIH Reporter #5R01AI172846-05
Structure and Function of Tetraspanin Complexes
Recipient
Harvard Medical School
Award Amount
$798,843.00
Ceiling
$798,843.00
Awarded
June 19, 2026
Identifier
5R01AI172846-05
Research project awarded to Harvard Medical School to study the structure and function of CD81 and C8 tetraspanins, aiming to provide insights into their roles in cellular functions and inform therapeutic strategies.
Description
The project aims to understand the molecular basis of the function of CD81 and C8 tetraspanins using structural, biochemical, and dynamic approaches. The work builds on recent progress in visualizing the structure of CD81. The project involves elucidating the dynamics of the CD19-CD81 co-receptor complex, recognition of ADAM10 by C8 tetraspanins, and how C8-tetraspanin binding modulates substrate selection and proteolytic activity. The project is funded by NIH grant PA-20-185 for the fiscal year 2026, ending in 2027.