Award
National Institute of Allergy and Infectious Diseases 1R21AI193594-01A1
Analysis of the AgrA-mediated transcription regulation in Listeria monocytogenes
Recipient
Tufts University Boston
Award Amount
$247,500.00
Ceiling
$247,500.00
Awarded
May 19, 2026
Identifier
1R21AI193594-01A1
Award for research on the transcriptional regulation of virulence genes in Listeria monocytogenes, focusing on the AgrA regulatory system to understand bacterial virulence mechanisms.
Description
This project aims to characterize the mechanisms of triple regulation of the agr locus and identify the direct targets of AgrA in Listeria monocytogenes, providing insights into how the bacterium senses its environment and modulates its virulence. The research involves in vitro and in vivo DNA affinity purification coupled with sequencing, high-resolution ChIP-Seq experiments, and transcription assays with purified proteins.