Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK077148-13
Metabolic and xenobiotic control of thyroid hormone metabolism
Recipient
University of Texas Medical Branch at Galveston
Award Amount
$423,748.00
Ceiling
$423,748.00
Awarded
February 24, 2026
Identifier
5R01DK077148-13
A research project funded by the National Institute of Diabetes and Digestive and Kidney Diseases to study the role of thyroid hormone signaling in liver development and its impact on metabolic diseases through epigenetic mechanisms.
Description
This project investigates how neonatal thyroid hormone signaling influences epigenetic modifications in the liver, affecting susceptibility to metabolic diseases in adulthood. The study aims to identify epigenetic mechanisms initiated by the neonatal D2-T3 peak affecting liver development and gene expression.