Award
National Institute of Neurological Disorders and Stroke 5F31NS139593-02
Impact of Developmental Glutamatergic Signaling on Oligodendrocyte Differentiation
Recipient
University of Colorado Denver, Aurora, CO
Award Amount
$39,079.00
Ceiling
$39,079.00
Awarded
May 29, 2026
Identifier
5F31NS139593-02
The project explores how neuronal activity modulates oligodendrocyte precursor cell development and myelination, utilizing chemogenetic tools to manipulate activity in mouse models. It aims to elucidate mechanisms of glutamatergic signaling in oligodendrocyte maturation and the long-term effects of early developmental alterations.
Description
This project investigates how neuronal activity influences oligodendrocyte precursor cell (OPC) differentiation and development, focusing on glutamatergic signaling pathways. Using designer receptors exclusively activated by designer drugs (DREADDs), the study modulates neuronal activity in mouse pups to observe effects on oligodendrocyte maturation and myelination, with implications for understanding neurological diseases.