Award
National Heart, Lung, and Blood Institute 5R01HL181372-02
Chromatin Regulation of Immune Cells in Myocardial Inflammation
Recipient
J. DAVID GLADSTONE INSTITUTES, SAN FRANCISCO, CA, UNITED STATES
Award Amount
$765,888.00
Ceiling
$765,888.00
Awarded
July 31, 2026
Identifier
5R01HL181372-02
NIH grant awarded to J. David Gladstone Institutes to study epigenetic regulation by BRD4 in immune cells during myocardial inflammation, aiming to develop therapies to reduce inflammation and improve heart failure outcomes.
Description
This project aims to elucidate the epigenetic mechanisms, particularly involving BRD4, that regulate monocyte differentiation and macrophage activation during myocardial infarction (MI). The research will focus on chromatin and gene regulatory networks to identify therapeutic targets that modulate maladaptive inflammation while preserving reparative functions.