Award
National Institute of General Medical Sciences 5R35GM145263-05
Transgenerational epigenetic regulation by Rlim
Recipient
UNIV OF MASSACHUSETTS MED SCH WORCESTER
Award Amount
$418,750.00
Ceiling
$418,750.00
Awarded
February 13, 2026
Identifier
5R35GM145263-05
This award supports research on the transgenerational epigenetic effects of the E3 ligase Rlim in Sertoli cells, focusing on offspring response to high fat diet and underlying molecular mechanisms.
Description
The research investigates the role of the E3 ligase Rlim in paternal testicular Sertoli cells and its impact on offspring's response to high fat diet (HFD). The study aims to elucidate molecular mechanisms, identify epigenetic signals in sperm, and uncover downstream effects in offspring.