Award
National Institute of Neurological Disorders and Stroke 5R01NS132674-03
HIV Tat-associated Sensory Neuropathy and the Contribution of Toll-like Receptor Pathway
Recipient
University of New England, Biddeford, ME, United States
Award Amount
$355,000.00
Ceiling
$355,000.00
Awarded
August 11, 2025
Identifier
5R01NS132674-03
Research project funded by the National Institute of Neurological Disorders and Stroke to study HIV-associated sensory neuropathy, focusing on the role of Toll-like receptor pathways and drug discovery using bioinformatics and preclinical models.
Description
This project focuses on understanding the mechanisms of HIV-associated sensory neuropathy and exploring potential therapeutic strategies targeting the Toll-like receptor pathway, with an emphasis on drug repurposing using bioinformatics tools. The project aims to determine the contribution of Tollip-regulated TLR pathways in HIV Tat-associated sensory neuropathy using genetically modified animal models and to identify potential drugs for HIV-SN by targeting TLR pathways through bioinformatics and preclinical testing.