Award
NIH Reporter #5R01CA298456-02
The STAT3 Pathway in Uterine Leiomyoma: A Therapeutic Target
Recipient
Northwestern University, Chicago, IL
Award Amount
$651,337.00
Ceiling
$651,337.00
Awarded
December 18, 2025
Identifier
5R01CA298456-02
Research project funded by the National Cancer Institute to study the STAT3 pathway's role in uterine fibroid growth and identify therapeutic targets.
Description
This project aims to investigate the role of the STAT3 pathway, which is hyperactivated due to MED12 mutations, in fibroid tumor growth. The research will explore how disruption of Mediator kinase activity influences STAT3 activity and promotes tumor growth, with the goal of identifying potential therapeutic targets. The study will utilize patient-derived xenograft models and advanced multiomics approaches to understand the cell populations involved and verify mechanistic findings in clinical samples.