Award
National Heart, Lung, and Blood Institute 5R01HL177599-02
Netrin-1 promotes the expansion and function of human hematopoietic stem cells by supporting a pro-hematopoietic vascular niche
Recipient
University of Florida, Gainesville, FL
Award Amount
$294,959.00
Ceiling
$294,959.00
Awarded
February 09, 2026
Identifier
5R01HL177599-02
This award funds research to develop a vascular niche platform using Netrin-1 to expand human hematopoietic stem cells, aiming to improve stem cell transplantation outcomes and hematopoietic recovery.
Description
The project aims to develop a novel vascular niche platform for the expansion of blood stem cells to enhance engraftment and regeneration following myeloablative treatments. It focuses on the pro-HSC factor Netrin-1 (NTN1) to improve ex vivo expansion and in vivo engraftment of human hematopoietic stem and progenitor cells (HSPCs), support vascular function during hematopoietic recovery, and identify candidate pro-HSC angiocrine factors from human endothelial cells. The goal is to expand the availability of suitable donors for hematopoietic stem cell transplantation and improve patient outcomes, including underserved populations.