Award
National Institute of Dental and Craniofacial Research 4DP5OD033055-04
Deconstructing aging with senolytic CAR T cells
Recipient
Cold Spring Harbor Laboratory
Award Amount
$960,000.00
Ceiling
$960,000.00
Awarded
August 07, 2025
Identifier
4DP5OD033055-04
This award funds research to develop CAR T cell therapies targeting senescent cells to treat age-related diseases, involving identification of senescent cell markers and preclinical validation.
Description
The project aims to identify surface molecules of senescent cells in aging, develop imaging strategies to monitor these cells in vivo, and create CAR T cells to selectively eliminate senescent cells. The work will explore the molecular program of senescence, validate surface markers, and assess therapeutic potential in preclinical models.