Award
National Institute of Neurological Disorders and Stroke 5U01NS123255-05
Optimization of Substituted Phenoxyalkyl Pyridinium Oximes as Therapies for Organophosphate Poisoning
Recipient
Mississippi State University
Award Amount
$641,224.00
Ceiling
$641,224.00
Awarded
August 26, 2025
Identifier
5U01NS123255-05
NIH awarded a grant to Mississippi State University to optimize substituted phenoxyalkyl pyridinium oximes as therapies for organophosphate poisoning, supporting further development and FDA approval.
Description
This project aims to optimize pharmacological and toxicological profiles of lead oxime compounds to advance toward FDA approval for treating organophosphate poisoning. It involves further characterization of a lead compound with survival efficacy tests, pharmacology, and toxicology information in two animal species to support future advanced development and FDA approval.