Award
National Institute of Neurological Disorders and Stroke 4R33NS126626-03
Investigational WNT-pathway modulators for the treatment and prevention of drug-resistant seizures
Recipient
University of Washington, Seattle, WA
Award Amount
$373,489.00
Ceiling
$373,489.00
Awarded
August 18, 2025
Identifier
4R33NS126626-03
A research project funded by the National Institute of Neurological Disorders and Stroke to study investigational WNT-pathway modulators as treatments for drug-resistant seizures and potential prevention of epilepsy using rodent models.
Description
This project focuses on characterizing investigational treatments for epilepsy using repurposed therapeutic agents targeting molecular pathways. It aims to establish pharmacokinetic and pharmacodynamic relationships and assess the potential to prevent epilepsy in rodent models. The study uses well-established rodent seizure and epilepsy models to evaluate the disease-modifying potential of two promising candidate compounds for the treatment and prevention of epilepsy.