Award
National Institute of Allergy and Infectious Diseases 5R01AI173406-04
Early life regulation of microbiota specific thymic T cell development
Recipient
Utah State Higher Education System--University of Utah, Salt Lake City, UT, United States
Award Amount
$817,057.00
Ceiling
$817,057.00
Awarded
December 05, 2025
Identifier
5R01AI173406-04
Research project funded by NIAID to study how early life microbial signals influence thymic T cell development in mice, aiming to identify molecular and environmental factors involved.
Description
This project investigates how microbial signals in the intestinal environment in young mice promote thymic T cell development, with aims to identify molecular signals and thymic environmental cues that regulate this process. Early life exposure to environments rich in microbial products corresponds with a more diverse microbiota and significantly decreases susceptibility to developing asthma and atopic sensitization.