Award
National Institute of Arthritis and Musculoskeletal and Skin Diseases 2R01AR044882-26A1
Transcriptional Co-Regulators in Epidermis
Recipient
University of California-Irvine, Irvine, CA
Award Amount
$578,509.00
Ceiling
$578,509.00
Awarded
September 15, 2025
Identifier
2R01AR044882-26A1
The award supports research on gene regulatory programs maintaining basal-to-spinous transition cells in epidermal differentiation, aiming to improve understanding of skin diseases related to defective epidermal differentiation and barrier formation.
Description
This project studies cellular composition, gene expression, and gene regulatory networks in epidermal differentiation using single-cell and spatial transcriptomics, single-nuclear ATAC-seq, and computational modeling. It addresses a recently recognized cell state in epidermal differentiation that has not been previously investigated.