Award
National Institute of Allergy and Infectious Diseases 5P01AI091580-15
The role of positive and negative regulation on ligand discrimination by the TCR signaling pathway
Recipient
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
Award Amount
$201,649.00
Ceiling
$201,649.00
Awarded
May 06, 2026
Identifier
5P01AI091580-15
NIH grant awarded to University of California, San Francisco to study T cell receptor signaling and ligand discrimination mechanisms, focusing on feedback regulation and LAT condensate formation.
Description
This NIH-funded project investigates the regulatory mechanisms of T cell receptor signaling, focusing on feedback loops and LAT condensate formation, to better understand immune response specificity and activation. The project involves computational modeling, biochemistry, mouse models, and single-molecule experiments to study T cell antigen receptor signaling and ligand discrimination.