Award
Eunice Kennedy Shriver National Institute of Child Health and Human Development 1R21HD117319-01A1
Modulation of Beta Oscillatory Rhythms in Stroke to Promote Corticomuscular Circuit Function
Recipient
University of North Carolina at Chapel Hill
Award Amount
$414,376.00
Ceiling
$414,376.00
Awarded
July 09, 2025
Identifier
1R21HD117319-01A1
This NIH-funded project aims to study and modulate beta oscillatory rhythms in stroke patients to improve corticomuscular circuit function and motor recovery using beta-burst rTMS.
Description
The goal of this proposal is to generate an enriched mechanistic understanding of post-stroke motor recovery by examining corticomuscular circuit function in adults with stroke. The study assesses neural oscillatory activity and functional connectivity between brain and muscle, focusing on corticomuscular coherence (CMC) in the beta frequency band (13-30 Hz). The research will determine the modulatory effects of beta-burst repetitive transcranial magnetic stimulation (rTMS) on CMC and motor performance, aiming to identify neurophysiological markers of responders and non-responders, and to evaluate behavioral relevance.