Award
National Institute of Allergy and Infectious Diseases 5R01AI099195-15
Role of ncRNA Surveillance Complex "RNA Exosome" in Class Switch Recombination and Somatic Hypermutation
Recipient
Columbia University Health Sciences
Award Amount
$789,949.00
Ceiling
$789,949.00
Awarded
April 07, 2026
Identifier
5R01AI099195-15
This NIH grant supports research on the role of the RNA exosome complex in B cell genome regulation, with potential implications for cancer and immunodeficiency therapies.
Description
The project investigates the topological organization and transcriptional regulation of the B-lymphocyte genome during development and antibody gene diversification. It focuses on the role of the noncoding RNA processing complex RNA exosome and its cofactors, including CTCF-binding element RNAs, in regulating AID activity, class switch recombination, and somatic hypermutation at immunoglobulin loci.