Award
National Institute of General Medical Sciences 5R35GM122564-09
Adeno-Associated Virus Gene Therapy Vectors: Molecular Interactions on Cell Entry
Recipient
University of Missouri-Columbia
Award Amount
$765,461.00
Ceiling
$765,461.00
Awarded
July 23, 2026
Identifier
5R35GM122564-09
Research grant for studying Adeno-Associated Virus interactions to enhance gene therapy vectors using structural biology techniques.
Description
This project focuses on the structural and mechanistic understanding of Adeno-Associated Virus (AAV) host interactions to improve gene therapy vectors. It involves cryo-electron microscopy, structural biology, and computer modeling to analyze AAV interactions with host cell receptors, antibody neutralization, and conformational changes during cell entry.