Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK132284-04
Structure-Guided Design of Intestine-Selective AHR Agonists for Restoration of Gut Barrier Integrity in IBD
Recipient
Beth Israel Deaconess Medical Center, Boston, MA, United States
Award Amount
$705,947.00
Ceiling
$705,947.00
Awarded
July 17, 2025
Identifier
5R01DK132284-04
The award supports research to develop intestine-selective AHR agonists aimed at restoring gut barrier integrity in inflammatory bowel disease, focusing on safety and efficacy in preclinical models.
Description
This project focuses on the design of intestine-selective AHR agonists to restore gut barrier integrity in IBD. It involves determining the modes of action of first-generation AHR agonists, designing compounds with limited systemic exposure, and evaluating their effectiveness in murine models.