Award
NIH Reporter #5R35GM154857-02
Pathways of peroxidation: defining the autoxidation of polyunsaturated fatty acids and the cellular consequences
Recipient
National Institute of General Medical Sciences (NIGMS)
Award Amount
$369,174.00
Ceiling
$369,174.00
Awarded
July 29, 2025
Identifier
5R35GM154857-02
Research project focused on defining lipid electrophile formation pathways via autoxidation of polyunsaturated fatty acids, using Staphylococcus aureus as a model, to inform therapeutic strategies.
Description
The project aims to define the pathways of lipid electrophile formation through autoxidation of polyunsaturated fatty acids in a model system, Staphylococcus aureus. The research involves using alkynyl PUFAs as tools for identifying protein targets of lipid electrophiles. The study will contribute to understanding the molecular mechanisms of lipid electrophile formation and cellular pathways involved, informing future therapeutic strategies.