Award
National Institute of General Medical Sciences 3R35GM139654-05S1
Mechanism of chromatin accessibility, 3D chromosome organization, and their functions in gene regulation
Recipient
PENNSYLVANIA STATE UNIVERSITY, THE, UNIVERSITY PARK, PA, UNITED STATES
Award Amount
$57,794.00
Ceiling
$57,794.00
Awarded
May 28, 2025
Identifier
3R35GM139654-05S1
The award funds research to compare and improve chromatin accessibility measurement techniques using MNase-seq and ATAC-seq, aiming to enhance understanding of gene regulation mechanisms.
Description
This project aims to perform MNase-seq and ATAC-seq on matched samples, conduct detailed bioinformatic comparisons, and develop a modified ATAC-seq method (shATAC-seq) to improve detection sensitivity. The project focuses on understanding chromatin accessibility and its role in gene regulation, which is essential for organism fitness and development, with implications for disease.