Award
National Institute on Aging 1R21AG091155-01A1
A Human iPSC-derived Microphysiological 3D model to study CAA/AD
Recipient
REGENERATIVE RESEARCH FOUNDATION, Albany, NY, United States
Award Amount
$428,175.00
Ceiling
$428,175.00
Awarded
February 06, 2026
Identifier
1R21AG091155-01A1
Development of a 3D human stem cell-derived model to study genetic and environmental factors affecting vascular pathology in Alzheimer's disease with CAA.
Description
This project aims to develop a state-of-the-art 3D human stem cell-derived model with open blood vessels to study how genetic risk factors such as APOE4 and environmental factors contribute to vascular pathology and potential reversal in Alzheimer's disease patients with Cerebral Amyloid Angiopathy (CAA).