Award
National Heart, Lung, and Blood Institute 5K08HL168348-02
Nocturnal hypoxemia dysregulates skeletal muscle protein homeostasis in COPD
Recipient
Cleveland Clinic Lerner Research Institute, Cleveland, OH, United States
Award Amount
$151,578.00
Ceiling
$151,578.00
Awarded
April 21, 2026
Identifier
5K08HL168348-02
Research project funded by the National Heart Lung and Blood Institute to study the molecular mechanisms by which nocturnal hypoxemia contributes to skeletal muscle wasting in COPD, focusing on HIF1α pathways to identify potential therapeutic targets.
Description
This project aims to identify how prolonged intermittent hypoxia (PIH), a common condition in COPD, dysregulates HIF1α-mediated responses leading to sarcopenia. The research involves in vitro and in vivo studies to elucidate the role of HIF1α in skeletal muscle protein synthesis and homeostasis, with the goal of discovering novel therapeutic targets.