Award
National Institute of General Medical Sciences 11257292
Centromere identity, strength, and regulation
Recipient
University of Pennsylvania
Award Amount
$632,821.00
Ceiling
$632,821.00
Awarded
December 16, 2025
Identifier
11257292
Research project funded by the National Institute of General Medical Sciences to study centromere identity and chromosome segregation using advanced imaging techniques.
Description
This project aims to advance understanding of chromosome inheritance, centromere function, and the molecular processes involved in chromosome segregation during cell division. The research focuses on the molecular basis of centromere identity, epigenetic propagation of centromeric chromatin, and chromosome segregation fidelity using cryo-electron tomography to visualize centromeres during mitosis and key cell cycle stages.