Award
National Institute of Allergy and Infectious Diseases 5R01AI172541-04
Sustained Release of Potent Antiviral Prodrugs for HIV Prevention
Recipient
Oak Crest Institute of Science
Award Amount
$808,442.00
Ceiling
$808,442.00
Awarded
June 25, 2026
Identifier
5R01AI172541-04
The project aims to develop a long-acting six-month implant system for HIV prevention using new potent anti-HIV compounds, improving adherence and clinical outcomes compared to daily oral dosing.
Description
This project focuses on developing a sustained-release implant for HIV prevention, involving chemical synthesis, drug screening, biomedical device engineering, and pharmacology. It aims to select potent anti-HIV compounds, formulate them for delivery, and test their safety and efficacy in animal models and humanized mice.