National Cancer Institute 11234778

Evaluating the role of the tumor macroenvironment in cancer cachexia

Research project funded by the National Cancer Institute to study the role of tumor macroenvironment in cancer cachexia, focusing on tumor-associated macrophages and liver dysfunction as drivers of cachexia.

Description

This research aims to uncover the mechanisms through which tumors and their microenvironments drive cachexia by disrupting systemic metabolism, focusing on interactions with critical metabolic regulatory organs (the TMaE). The study will investigate tumor-associated macrophages (TAMs) and their role in muscle and fat wasting, as well as liver-mediated pathways involved in cachexia.

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