Award
NIH Reporter #11264782
Antibodies against Oxidized Phospholipids and Osteoporosis
Recipient
CENTRAL ARKANSAS VETERANS HLTHCARE SYS, NORTH LITTLE ROCK, AR, USA
Awarded
December 11, 2025
Identifier
11264782
This award supports research on the role of antibodies against oxidized phospholipids in preventing bone loss and osteoporosis, including animal studies and human cohort analyses to explore therapeutic potential.
Description
The project investigates the mechanisms by which the natural antibody E06 IgM causes bone anabolism and whether injections of a murine monoclonal E06 IgG increase bone mass in mice. It also studies the correlation of anti-PC IgM antibody levels with bone mineral density and fractures in human cohorts. The goal is to develop novel therapies for osteoporosis and age-related diseases.