Award
National Institute of Neurological Disorders and Stroke 5R01NS132493-04
The Role of Dendritic Cells in Regulating the Gut-Brain Immune Axis in Ischemic Stroke
Recipient
WEILL MEDICAL COLL OF CORNELL UNIV
Award Amount
$455,141.00
Ceiling
$455,141.00
Awarded
February 19, 2026
Identifier
5R01NS132493-04
Research grant investigating how intestinal microbiota and dendritic cells affect stroke outcomes, aiming to develop new prevention and treatment strategies through immune modulation.
Description
This project aims to elucidate the role of intestinal microbiota in stroke pathobiology and develop new preventative and therapeutic strategies by testing the hypothesis that microbiota interact with dendritic cells to influence stroke outcomes by modulating immune responses. The research involves mouse models of cerebral ischemia, altered gut bacteria, immune cell tracking, and in vitro coculture models.