Award
National Heart, Lung, and Blood Institute 1R01HL183876-01
Role of Hydrogen Sulfide in Exercise Intolerance in HFpEF
Recipient
LSU PENNINGTON BIOMEDICAL RESEARCH CTR, BATON ROUGE, LA, UNITED STATES
Award Amount
$736,602.00
Ceiling
$736,602.00
Awarded
June 26, 2026
Identifier
1R01HL183876-01
The award funds research to understand how hydrogen sulfide contributes to exercise intolerance in HFpEF by studying skeletal muscle dysfunction and testing targeted therapies.
Description
This project investigates the role of hydrogen sulfide (H2S) in exercise intolerance in heart failure with preserved ejection fraction (HFpEF). It focuses on the dysfunction of skeletal muscle metabolism and perfusion as primary drivers of exercise intolerance, examining the roles of enzymes CSE and 3-MST in endothelium and skeletal muscle, mitochondrial H2S in muscle function, and testing mitochondrial-targeted H2S therapy.