NIH Reporter #5R01CA251663-05

Targeting Mitochondrial Redox Capacity to Overcome Cancer Subtype that Regrowth After Radiation

A research project funded by the National Cancer Institute to study mitochondrial biogenesis mechanisms in radiation-resistant prostate cancer and to improve radiation therapy efficacy by targeting mitochondrial redox capacity and biogenesis.

Description

This project aims to establish the underlying mechanism(s) of mitochondrial biogenesis that contribute to radiation-resistant prostate cancer (RR-PCa) cell survival and metabolism and to determine if targeting inherent mitochondria and radiation-acquired mitochondria can overcome RR-PCa. The project will use state-of-the-art platforms to uncover novel molecular insights by which concurrently targeting mitochondrial redox capacity and mitochondrial biogenesis improve radiation therapy efficacy of RR-PCa.

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