Award
National Institute of Neurological Disorders and Stroke 5R01NS129191-05
Small extracellular vesicles mediated signaling and pain
Recipient
Drexel University
Award Amount
$382,851.00
Ceiling
$382,851.00
Awarded
June 30, 2026
Identifier
5R01NS129191-05
NIH grant awarded to Drexel University to study the role of small extracellular vesicles in immune regulation and pain attenuation, with a funding amount of $382,851 for the project duration from September 1, 2022 to May 31, 2027.
Description
This NIH research grant opportunity focuses on understanding how small extracellular vesicles secreted by monocytes/macrophages regulate immune cells and influence immune memory in microglia to attenuate pain. The study investigates the prophylactic potential of serum-derived sEVs in inflammatory pain models, their role in immune regulation, and epigenetic immune memory in spinal microglia.